How Re-Gen Solves the Reliability Problem in Biologicals

A bucket of Re-Gen stands ready to be used in a field of residue.
June 03, 2025
Charles SmithCo-Founder & CEO

Biologicals have been around for decades. And for just as long, farmers have heard the same promise: that these natural products can reduce dependence on synthetic inputs while maintaining or improving yields.

But here’s the problem: most biologicals don’t deliver consistent performance or ROI.

They sound good in theory, but in the real world—with its unpredictable weather, soil variability, and tight planting windows—the one that you farm in—they rarely perform as advertised. Ask any agronomist, and you’ll hear it again and again: Biologicals just aren’t reliable.

At IMIO, we’ve spent years working to change that.

Why Most Biologicals Miss the Mark

The truth is, most biologicals need a lot of things to go right in order to work.

They’re sensitive to heat and handling. Many lose effectiveness in shipping or storage, long before they reach your soil. Farmers were often told to just mix them in with their usual inputs without being warned that herbicides, fungicides, or even water quality could kill off the microbes.

And once they were in the field? The microbes still had a long list of hurdles: survive harsh field conditions, colonize plant roots, form multi-stage symbiotic relationships, all while competing with native microbes in the soil.

Some growers saw benefits. Many didn’t. What sounded great in the sales pitch often didn’t show up on the yield monitor.

That’s not a reliable tool. That’s a roll of the dice.

Enter Re-Gen: The Bulletproof Biological for Nutrient Recapture

Re-Gen was designed to take the chance out of using biologicals. We re-engineered the biological from the ground up to deliver consistent, reliable performance and ROI across crops, climates, and soil conditions.

Here’s what makes Re-Gen different:

Shelf-Stable Storage

Re-Gen is freeze-dried into a shelf-stable powder using a specialized lyophilization protocol. No refrigeration required. No viability loss in transit. 

Consistent Microbial Activity

Because Re-Gen is freeze-dried and activated on site, it delivers 100,000X more active microbes than leading competitors. Guaranteed.

Performance Proven in the Field

In field trials spanning over 1,100 acres and multiple regions, Re-Gen has consistently delivered:

  • +20 bpa corn yield increases
  • 40–50 lbs nitrogen credit
  • 3.9% milk yield increase (from more nutritious silage)
  • 5.4x ROI

That’s why we believe Re-Gen isn’t just a better biological. It’s a better agricultural input, period.

Why Re-Gen Works When Others Don’t

Re-Gen isn’t just more reliable because of what it does. It’s reliable because of how it does it.

While other biologicals depend on a complex chain of events—microbial colonization, symbiosis, perfect soil conditions—Re-Gen takes a more direct route: breaking down crop residue to unlock the nutrients already in your field.

That straightforward, mechanical action means fewer points of failure and far more consistent results.

Consistency You Can Count On

Reliability isn’t just about biology. It’s also about manufacturing.

Each of the microbes in Re-Gen is cultured and tested individually, then blended in precise ratios to ensure consistency from batch to batch. That means the product you use this season will perform just like it did last season.

Work With a Biological You Can Trust

Farmers don’t have time for products that only work some of the time. You need tools that deliver a return: reliably, repeatably, regardless of what the season throws at them.

That’s a high standard. But it’s one that Re-Gen is ready to meet.

So if you’ve been burned by biologicals in the past—or you’re just tired of hoping something works—give Re-Gen a closer look.

Want to see what Re-Gen can do in your fields? Let’s talk.

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